HBA-DEALS: accurate and simultaneous identification of differential expression and splicing using hierarchical Bayesian analysis

HBA-DEALS: accurate and simultaneous identification of differential expression and splicing using hierarchical Bayesian analysis

Blog Article

Abstract We present Hierarchical Bayesian Analysis of Differential Expression and ALternative Splicing Pasta Cookers (HBA-DEALS), which simultaneously characterizes differential expression and splicing in cohorts.HBA-DEALS attains state of the art or better performance for both expression and splicing and allows genes to be characterized as having differential gene expression, differential alternative splicing, both, or neither.HBA-DEALS analysis of GTEx data demonstrated Unclassified sets of genes that show predominant DGE or DAST across multiple tissue types.

These sets have pervasive differences with respect to gene structure, function, membership in protein complexes, and promoter architecture.